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Presumably, the HMGA2-induced DNA damage may initialize the caspase-2 activation and further active the downstream effecter caspases through MOMP.
KRAS is well established as an important downstream effector of the EGFR signaling pathway, and mutational activation of KRAS by further active downstream effectors like ERK induces drug resistance to EGFR antagonists (for example, cetuximab) [ 39].
That forms the basis for the further active quest for solutions.
This battle was the capstone of Farragut's career, but poor health precluded further active service.
"It needs to be acknowledged that some doctors remain reluctant to make that call, associating a decision not to pursue further active treatment as an acceptance of failure".
As I indicated earlier today, I have been giving further active consideration as to whether it would be appropriate to provide more information.
Similar(13)
And then that amplification allows you get further active amplification is something that's used as a communication strategy everywhere, including in the dendritic tree.
Indeed, removing non-active atoms excludes the possibility of further having active components in the neighborhood of already suppressed atoms.
Further, the active form of MMP-11 and both, inactive and active forms of MMP-23 were detected.
Further, general active boundary condition elements are defined.
Moreover, researchers have applied surface functionalities on ferritin cages for further providing active tumor targeting.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com