Sentence examples for further activating from inspiring English sources

Ceramide mediates inhibition of cyclooxygenase-2 (COX-2) which catalyzes formation of prostaglandin further activating peroxisome proliferator-activated receptor γ (PPAR γ ) and Wnt/ β -catenin pathway; and hence plays a critical role in cancer.

Active yields were improved by mutating the cell extract source strain to reduce proteolysis, adjusting reaction conditions to enhance oxidative protein folding, further activating energy metabolism, and encouraging post-translational activation.

Also cytochrome c, which is released from mitochondria upon activation of apoptotic pathways, can bind IP3Rs at the MAMs, further activating the Ca2+ flux and enhancing apoptotic signaling [ 65].

Further activating mutations of the GNAS gene have been identified in kidney, thyroid, adenocortical, colorectal and Leydig cell tumours60.

Further, activating mutations in FGFRs have been identified in a variety of human cancers and, most relevant to the YC-XLH, skeletal disorders.

The interaction of IP3 with its receptors in the endoplasmic reticulum up-regulates the level of Ca2+ in the cytosol, further activating the Ca2+-binding protein calmodulin.

The activated ULK1 could further activate the other important complex, Beclin1-Vps34-Atg14L-p150 complex, by phosphorylating Beclin1 [ 12, 13].

The activated form of DAPK further activates the Beclin-1 by phosphorylation.

Once activated by upstream phosphorylation, p38 MAPK further activates downstream transcription factors, MAPK-activated protein kinases, and caspases.

It is conceivable that THC activation of CB2 receptors could further activate intracellular signaling pathways that affect nuclear transcription factors involved in the induction of P-gp (Mestre et al, 2006).

The sustained activation of the amygdala, in turn, further activates stress system neuroendocrine and autonomic functions.