DU145 cells were fundamentally very resistant to copper with no significant inhibition of growth being apparent at metal concentrations of 100 μM and lower (Fig. 1A).
Wind exposure categories are currently used to account for the influences of different ground roughness in wind profile that is fundamentally important to wind-resistant structural analysis and design.
Essentially, therefore, the flora is divided into two components with fundamentally different demographics: fire-resistant (resprouter) populations are relatively stable, persistent and impervious to disturbance by fire, and fire-killed (reseeder) populations are more variable and susceptible to local extinction after fire [ 18, 21, 22].
Supersusceptible and resistant classes were fundamentally based on survival, whereas susceptible mice were those that survived to day 35 without external evidence of morbidity but had lost weight upon retrospective analysis.
Its governance, moreover, is not forever fixed, centralised and resistant to change, for it is fundamentally a thing of rules and institutions and not mere domination; and it is not an empire in any meaningful sense of the term".
Like P-gp, MRP is located in the plasma membrane of resistant tumour cells; however, the mechanism of MRP might be fundamentally different from that of P-gp.
As PCa is fundamentally androgen receptor (AR) driven, we performed similar studies in AR-positive docetaxel-resistant cells.
Most models dealing with drug resistance can be described as 'population dynamics' approaches, fundamentally concerned with demography, and extended to consider genetic heterogeneity by subdividing the relevant population into drug-sensitive and drug-resistant variants with distinct demographic parameters.
The message is very disturbing as the clones he mentions are not resistant; they're at most less susceptible and hence only postpone the problem, but don't tackle it fundamentally," he says.
