However, syntheses, by definition, combine data sources that have fundamentally different purposes, contexts, designs and sources of error and bias; they may thus provide contradictory results, not because of the biological phenomena of interest, but due instead to combining diverse data.
The results obtained from the necessity study (MEK siRNA) and sufficiency study (LeTx and MEKcr) are not actually contradictory as the two experimental systems model fundamentally different cellular contexts.
First, one might distinguish between two fundamentally different sorts of referential terms: context-sensitive referential terms and context-insensitive referential terms.
These dichotomies are notable, because, while they do not usually affect how experts interpret questions, students often view the opposing contexts as fundamentally different.
But today's context is fundamentally different.
However, the nature of white identity in this context is fundamentally different.
Despite the rigorous definitions used to characterize individuals as latently infected, it appears that, like active TB, latent TB may be a fundamentally different immunological phenomenon in the context of HIV co-infection.
So although legal cynicism may be less applicable or fundamentally different in non-US or rural contexts, e.g. the role-taking process through which a relevant local cultural frame influences appraisals of behaviour is a general process (Mead 1934) and, therefore, likely has explanatory power, regardless of the larger context.
However, these studies suffer from the same problem as Berry's work, as the studies compare fundamentally different groups, mainly in the US context (Hirschman, 2001; Kao & Tienda, 2005; Perreira, Harris, & Lee, 2006).
