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"fundamentally challenge" is a correct and usable phrase in written English.
It is typically used to express a significant or deep level of challenge to a particular concept, belief, or idea. Example: "The new research findings fundamentally challenge the commonly accepted theory on the origins of the universe."
Exact(34)
However, there are a number of trends and associated risks emerging in Asia at the present time that fundamentally challenge this assumption -- namely, heightened competitiveness, weakening economic fundamentals, rising economic nationalism, and an increasing orientation toward militarism.
For that reason, my cochlear implant didn't fundamentally challenge my sense of autonomy and selfhood.
The yuppies were too fast and too crass, but they didn't fundamentally challenge Old Money's culture.
In doing so, they alter cultural sectors and fundamentally challenge traditional organizations and revenues.
As these issues fundamentally challenge characteristics of their professional identity, there is internal resistance against this transformation.
We rarely hear about them, because they fundamentally challenge a world view that regards the market as solution and saviour.
Similar(26)
It was an approach Mr. Gorbachev had not fundamentally challenged.
The economic dominance of the West has been fundamentally challenged in the era of globalisation.
Mr. Reagan's proposals in 1980 fundamentally challenged conventional economic and strategic assumptions.
This is a monumental task that fundamentally challenges the way care is designed and delivered.
The document, written in Latin, fundamentally challenged the authority of the Roman Catholic church.
More suggestions(15)
fundamentally challenging
completely challenge
deep challenge
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fundamentally called into question
dramatically challenge
absolutely challenge
mainly challenge
radically challenge
substantially challenge
totally challenge
fundamentally contested
fundamentally questioned
fundamentally business
fundamentally problem
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com