Sentence examples for fundamental upstream from inspiring English sources

It could be that Indigenous disparities in receipt of DGA care (along with many other health outcomes) will persist until such fundamental upstream factors are addressed.

In contrast, the 'simple' loss-of-function hypothesis proposes that Aβ alterations are only an epiphenomenon of the PSEN mutations, and that inefficient cleavage of membrane proteins by γ-secretase complexes is the fundamental upstream cause of the neurodegenerative process (Shen and Kelleher, 2007; Kelleher and Shen, 2010).

This molecular difference was not so surprising, since the transcriptional outputs of Hippo signalling are known to differ significantly between flies and mammalian cells [ 35], and Bossuyt et al. recently reported fundamental differences in the upstream regulatory mechanisms of Hippo signalling between Drosophila and mammals [ 36].

Thus, Snail1 lies upstream of three fundamental pathways in bone remodelling and the control of adult bone mass.

Such fundamental dependency on the most upstream external compounds should intrinsically constrain sustained evolutionary elongation of multi-step metabolic pathways needed for color elaboration unless the metabolic network gains robustness – the ability to synthesize the same carotenoid from an additional dietary starting point.

Such approaches would likely also capture those at risk of developmental problems [ 24], demonstrating the benefit of upstream approaches addressing this fundamental determinant of health.

Major impairment of IS was confirmed by reduced upstream and downstream mTOR molecules which regulate fundamental cells metabolic functions.

These upstream and downstream kinases of AMPK have fundamental roles in glucose metabolism, fatty acid oxidation, protein synthesis and tumour suppression; consequently, they have been implicated in cardiac ischaemia, arrhythmias and hypertrophy.

An increasing number of pro-metastatic miRNAs and anti-metastatic miRNAs are identified as upstream regulators of metastasis related genes and have a fundamental role in the invasion and metastasis of HCC cells.

Investigation of protein activation in living cells is fundamental to understanding how proteins are influenced by the full complement of upstream regulators they experience.

The core challenge is whether the UK's bulk communications interception program — and how UK state agents can receive data via similar US programs (Tempora, Prism and Upstream, respectively, as revealed by the Snowden disclosures) — interferes with fundamental rights under the European Convention of Human Rights.