Sentence examples for fundamental spindle from inspiring English sources

Interestingly, the incidence of embryonic aneuploidies in other chromosomes was very low, again in contradistinction to prior reports (Kuliev and Verlinsky, 2004) and arguing against a fundamental spindle abnormality that might predispose to other meiotic aneuploidies (Magli et al., 2012).

Kinesin Eg5 is one fundamental spindle motor protein and its specific role during mitosis in the assembly and maintenance of the bipolar spindle has rendered it an attractive therapeutic target that could prevent cell cycle progression through mitosis and promote tumor growth regression [ 8- 10].

Tubulins are a family of eukaryotic structural proteins that comprise microtubules, fundamental components of the spindle in cell division, the axoneme in cilia and flagella, mediators of cell shape, and dynein/kinesin-based cell trafficking [ 13- 15].

DOI: http://dx.doi.org/10.7554/eLife.02875.002 The fundamental functions of the mitotic spindle include not only the faithful partition of the genome into both daughter cells, but also controlling whether cell fate determinants are distributed symmetrically or asymmetrically to those daughters (Gonczy, 2008; Gillies and Cabernard, 2011).

Since Nlp has a fundamental role in MT nucleation, spindle formation and cytokinesis, and is subjected to a complex post-modification by mitotic kinases, its proper abundance with correct phosphorylation state at each mitotic phase is a prerequisite for precise execution of the mitotic events and cell division (Casenghi et al, 2003, 2005; Jin et al, 2009; Yan et al, 2010; Zhao et al, 2010).

The origin, development and function of the diffuse anastral spindle of land plants are fundamental questions in evolutionary and developmental biology.

Meiotic spindles in mammalian oocytes show some fundamental differences from their mitotic counterparts and little is known about the force generation mechanism in the meiotic spindle to move chromosomes from spindle equator to poles.

The following paper comprises the novel process approach, fundamental process investigations, the design of a spindle-tool system with integrated beam guidance, laser control and first investigations with the new system.

For the stable operation of high speed air spindles, the low rotational inertia and high damping ratio of spindle shafts as well as high fundamental natural frequency are indispensable.

This system is analogous to the cytostatic factor (CSF) arrested meiosis II extract derived from unfertilized X. laevis eggs, which has facilitated fundamental discoveries pertaining to the cell cycle and spindle assembly (Maresca and Heald, 2006).

By contrast, astrals that reach the central cell cortex (medium green rods) of neural progenitors may be more involved in the fundamental establishment of a centrally located and functional bipolar spindle that can congress, and then faithfully segregate, chromosomes.