Sentence examples for fundamental signalling pathways from inspiring English sources

The tribbles family of proteins are being recognized as modulators of many fundamental signalling pathways, biological processes and disease pathologies [ 1, 2].

Notch is a fundamental signalling pathway in many mammalian cell types undergoing differentiation, primarily acting to regulate cell fate determination.

We hypothesize that an imbalance of fundamental signaling pathways should affect multiple ectodermal organs in a spatio-temporal-dependent manner.

EF and LF affect fundamental signaling pathways linking extracellular stimuli to cell function.

This could be due to the fact that the mib mutants are defective in Notch signaling, which is one of the fundamental signaling pathways required for proper development of an organism.

Over the past two decades, the successful development of tyrosine-kinase inhibitors (TKIs) that disrupt several fundamental signaling pathways has marked a notable advance in the fight against cancer.

Thus, our data point toward a physiological role of prion protein in synaptic function and will thereby help understanding the fundamental signaling pathways of prion proteins and their involvement in prion pathogeneses.

The PI3K pathway is a fundamental signaling pathway for regulation of cell proliferation, survival, migration, and metabolism [5].

This study not only provides further understanding of how the fundamental signaling pathway, Notch signaling, and its downstream genes mediate neural development and differentiation, but also reveals evolutionary diversity in the role of H/E spl) genes.

Notch is a fundamental signaling pathway that regulates embryonic cell fate specification, proliferation and patterning [ 1, 2].

EPC mobilization is characterized by both a loss in cell-cell contacts and a desensitization of chemokine signaling, notably the SDF-1α/C-X-C chemokine receptor 4 (CXCR4) axis, the fundamental signaling pathway underlying stem cell mobilization and homing during tissue homeostasis and injury (10).