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One instance, the evolution of antifreeze glycoproteins from trypsinogen-like proteases in Antarctic notothenioid fish [ 69], demonstrates how gene duplication can be followed by fundamental remodelling of primary structures, involving the loss of functional domains and very low sequence identities, of the magnitude recorded in T. brucei.
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Instead, the difference in stress response between the runners and the sedentary animals reflected fundamental remodeling of their brains.
Similarly, purinergic signalling has a fundamental role in remodelling and healing of lesions in other tissues, including skin and bone.
Remodelling of vascular connective tissue should be of fundamental importance as DD progresses over time and the ability of that tissue to be remodelled could be an important factor in the development of the disease.
Membrane fusion is a fundamental biological phenomenon ranging from intracellular vesicle fusion and mitochondrial remodelling to virus entry, fertilization, myogenesis, and osteoclastogenesis.
Although they are quantitatively minor components of cell membranes, the PIs regulate many fundamental processes in the cell, including membrane trafficking, cell growth, cytoskeleton remodelling and nuclear events.
During the early wound-healing process, the activation of keratinocytes plays a fundamental role in epithelial remodeling [ 31], with prolonged proliferation probably being associated with hypertrophic scarring [ 32].
By generating energy (ATP and NAD+), and regulating subcellular Ca2+ and redox homoeostasis, mitochondria may play important roles in controlling fundamental processes in neuroplasticity, including neural differentiation, neurite outgrowth, neurotransmitter release and dendritic remodelling.
Macrophages have a fundamental role in the inflammatory response and are often found at sites of intense tissue remodelling.
Recent efforts in genomics have provided new tools to address fundamental questions regarding fish health, ecology, physiology, and genetics, as well as allowing investigation of post-tetraploidization genome remodelling [ 29- 34].
There was constant remodelling".
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