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It was hypothesized that YB-1 is a fundamental regulatory factor of the MDR1 gene in tumor cells and can therewith enhance drug resistance.
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Recent evidence obtained from our laboratory suggested a fundamental role for Na+/H+ exchanger regulatory factor 1 (NHERF1) in human breast and colorectal cancers.
Even if some of the transcription factors were unrelated to these cancers, uncovering a fundamental regulatory program like smooth muscle-specific regulation supports our assertion that we can find meaningful gene regulatory networks and key factors behind them.
3– 5 Hsps are fundamental regulatory elements of cellular networks as they interact with a large number of proteins such as kinases, transcription factors and several other proteins influencing key steps in protein homoeostasis, cell growth, division, apoptosis and development.
It is also a fundamental regulatory requirement.
Interferon regulatory factor.
Legal liability plays a fundamental regulatory function.
interferon regulatory factor 7. myeloid DC. peripheral blood mononuclear cell.
However, we still lack information about some basic aspects of this fundamental regulatory mechanism.
IFN regulatory factor 9. IFN-stimulated gene factor 3. IFN-stimulated response elements.
The depth and breadth of conservation of these sequences is indicative of a fundamental regulatory role.
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