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3– 5 Hsps are fundamental regulatory elements of cellular networks as they interact with a large number of proteins such as kinases, transcription factors and several other proteins influencing key steps in protein homoeostasis, cell growth, division, apoptosis and development.
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Identification of an identical regulatory sequence in two different and functionally diverse genes suggests that this could be a frequent motif that can function in SF2/ASF mediated recognition of weak 5′ splice sites as well as weak 3′ splice sites, and suggests that this motif could also function as a fundamental splicing regulatory element in other genes.
The differences between the actions of corazonin in the different sexes suggest fundamental differences in regulatory elements of the neural circuitry in males and females.
Chromatin modifications are key for distinguishing regulatory elements [ 7, 17].
The massive sequencing of eukaryote genomes has lead to an unprecedented discovery of fundamental features of an abundant class of non-coding regulatory elements, the microRNAs (miRNAs).
Furthermore, the choice of appropriate regulatory elements in rAAV vector design is of fundamental importance to achieve high-level sustained in vivo transcription and translation.
As miRNAs turn out to represent crucial regulatory elements, sharing common principles with transcription factors, it is fundamental to establish their distribution and decipher their functional role in the eye in order to obtain a complete picture of the gene networks operating therein in health and disease states.
The identification of transcriptional regulatory elements that control the expression of each transcript is a fundamental and challenging problem in biology.
Highly conserved enhancer sequences can regulate fundamental processes, such as embryonic development, and this property has been used to screen for functional regulatory elements (Pennacchio et al., 2006).
In the second phase, functional genomics, genome-wide association studies, and fundamental molecular biology efforts led to substantial annotation of the tens of thousands of genes and other noncoding regulatory elements within these genomes.
It is also a fundamental regulatory requirement.
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