Sentence examples for fundamental processes leading from inspiring English sources

Specifically, somatic cellular selection and evolution are the fundamental processes leading to malignancy, metastasis, and resistance to therapies, with the contribution of cancer stem cells as the progenitors of these more differentiated cell types (Shipitsin and Polyak 2008; Greaves this volume).

Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenesis, evasion of the immune system, metastasis, and resistance to therapies).

However, evidence from studies of DC in humans as well as in vitro studies on human cells, strongly implicates telomerase and telomeres in the fundamental processes leading to DC and there is considerable evidence showing normal functioning of pseudouridylation and rRNA precursor processing in human cells with DKC1 mutations [35,50].

These results, including the elucidation of the fundamental collisional processes leading to the chemiluminescence, may be contrasted with the observation of such emission, where feasible, in low pressure flames.

Current evidence suggests that OSA disturbs fundamental biochemical processes, leading to low-grade systemic inflammation and oxidative stress.

Seismicity patterns vary substantially from place to place, showing various clustering features, though some of the fundamental physical processes leading to earthquakes may be common to all events.

Therefore, the aim of the currently proposed therapeutic approaches and strategies for AD is to counteract the fundamental underlying pathological processes leading to the development and progression of the disease.

Interactions of oligomers formed by amyloid-β (Aβ) peptides with the plasma cell membrane are believed to play a fundamental role in the processes leading to membrane permeability.

Notwithstanding this, these results suggest that, given its high expression levels in neoplastic tissues, Hsp90 could hold a fundamental role in the multiple processes leading to carcinogenesis and tumour progression in the canine mammary gland.

Hydrogels that combine these functionalities can provide a fundamental tool to promote specific cellular processes leading to tissue formation.

Fruit ripening behaviour can also be divided into two classes (climacteric and non climacteric), according to the level of ethylene, a plant hormone fundamental for triggering and coordinating the processes leading to the final quality of fruit [[ 4],[ 5]].