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The phrase 'fundamental problem with' is correct and usable in written English.
You can use it to refer to a major issue underlying a complex matter or issue. For example: "There is a fundamental problem with the current economic model which has to be addressed."
Exact(60)
"That's the fundamental problem with long-term investing.
There is a fundamental problem with the idea, however.
"I think there's a fundamental problem with philanthropy," Hayman says.
There is another, more fundamental problem with economic forecasting.
"There's a fundamental problem with the F.H.A.," Mr. Pinto said.
The fundamental problem with the ballot-process "market" is that there isn't enough competition.
Bernard Jenkin, the committee chairman, said he thought there was "a fundamental problem" with Heywood's investigation.
There seems to be a fundamental problem with the design of the project here.
But the fundamental problem with "The Real World Movie" may be deeper than that.
The fundamental problem with the privatisation of public services is that, once they're gone, they're gone.
The theory also solves a fundamental problem with the Higgs boson.
More suggestions(16)
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basic problem with
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fundamental challenge with
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underlying problem with
basic issues with
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com