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The phrase "fundamental problem in" is correct and usable in written English.
You can use it to refer to a basic or core problem in a particular area of life or study. For example, "Poor nutrition is a fundamental problem in developing countries."
Exact(60)
"The fundamental problem in all this is the ways we estimate extinction intensities are totally different".
"I think that this is unfortunately a fundamental problem in cancer," Dr. Bissell said.
He said Britain had a fundamental problem in supporting innovative businesses.
I knew ribosomes were a big fundamental problem in science and this was a method for chipping away at it".
The fundamental problem in the economy, he asserted, is still a preponderance of unneeded capacity for production.
Mr. Leonhardt defines the "fundamental problem" in health care as "the combination of soaring costs and mediocre results".
But the fundamental problem in Britain's immigration debate is cowardice and dishonesty on the part of political leaders.
The fundamental problem in all of this is that ritual is described from an observer's point of view.
As he sees it, the fundamental problem in the United States can't be solved by the Fed.
Material recognition is a fundamental problem in computer vision.
Controller parameterization is a very fundamental problem in control theory.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com