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A fundamental problem exists in addition to this, which is that the ADHD construct is based on behavioural symptoms and therefore includes heterogeneous populations of children with different cognitive and behavioural dysfunctions.
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"The fundamental problem that exists with these people is that there are people who believe them.
A fundamental problem that exists with most passive FCDs is how they respond to breakthrough for unwanted fluids.
"Well, the problem exists".
A new problem exists.
Clearly, a problem exists.
The problem exists elsewhere.
Denying that the problem exists.
This review addresses fundamental problems that exist in experimentally measured binding energies (BEs) stored in various numerical X-ray Photoelectron Spectroscopy (XPS) data-banks, including, for example: (1) PHI Handbook of XPS (1979), (2) NIST SRD-20 XPS Database, v1.0 4.1 (1989–2017), (3) Wiley Practical Surface Analysis 1st and 2nd ed.
A primary and fundamental problem which still exists in the field is a lack in the understanding of how epithelial CFTR is processed, what the exact nature of CFTR's stoichiometry is, and what epithelial accessory proteins interact with epithelial CFTR in the ER, in the Golgi and other organelles, and at the plasma membrane.
A problem existed though.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com