The obvious problems of graft and the revolving door between government and industry, in other words, were really symptoms of a more fundamental pathology: regulation itself became delegitimatized, seen as little more than the tool of Washington busybodies.
The physician-scientist may study the same properties of the same molecule but for a different reason: because he or she believes that those studies will provide information on the fundamental pathology of a disease or insight into human biology that will provide a better understanding of healthy versus diseased states.
Obesity is a fundamental pathology of cardiometabolic abnormalities, such as hypertension, type 2 diabetes, and dyslipidemia.
Recently the synaptic hypothesis of schizophrenia has gained attention by attributing the fundamental pathology of schizophrenia to the dysfunction of synaptic transmission involving various molecules [ 4].
13 In contrast to earlier SLE treatments, belimumab is targeted at the fundamental pathology of SLE and has been widely interpreted as representing a step change in treatment options.
We have proposed that the fundamental pathology in FMSS is the presence of overly precise priors at intermediate levels of the hierarchy, which may lead to the overweighting of bottom-up inputs that accord with those priors.
The fundamental pathology of type 1 diabetes is autoimmune-mediated beta cell destruction, which results in an absolute deficiency of insulin, with only about 1% of beta cell mass remaining in individuals with lifelong type 1 diabetes at autopsy [ 66, 67].
This suggests that there may be fundamental differences between the underlying pathology of these two PE forms.
CSF biomarkers related to fundamental AD pathology hold great promise in the early and accurate prediction of underlying AD neuropathology, and there is ongoing effort to standardize operating procedures between laboratories to establish universally applicable models of AD diagnosis.
GPCRs regulate essentially all cellular processes, including those that are fundamental to cancer pathology, such as proliferation, survival/drug resistance, migration, differentiation, tissue invasion, and angiogenesis.
