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The fundamental pathogenesis of autoimmune disorders lies on the loss of immune tolerance to self-antigens.
And although excess cardiovascular and pulmonary deaths have been linked to exposure to air pollution in many developed countries, we still don't understand the fundamental pathogenesis of these diseases or why some individuals are more susceptible to these complications.
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The clinical characteristics of familial and sporadic ALS are nearly indistinguishable, and it has long been hoped that understanding familial ALS would shed light on the fundamental processes underlying the pathogenesis of the more common sporadic form of the disease.
Inflammation is fundamental to the pathogenesis of ARDS and a variety of inflammatory biomarkers have been assessed for prognostic utility.
This condition may play a role in promoting the sensitization of trigeminovascular afferents and sterile inflammation within the dura mater that are fundamental to the pathogenesis of migraine headache.
Insufficient pancreatic β-cell mass is fundamental to the pathogenesis of both types 1 and 2 diabetes and constitutes the basis for the goal of β-cell replacement therapy.
However, whether these abnormalities are fundamental to the pathogenesis of PV was unclear.
The behavior of DCs and macrophages are fundamental to the pathogenesis of flaviviruses, although the balance of their beneficial versus deleterious effects depends on the regulation of their activity [13].
Insulin resistance is fundamental to the pathogenesis of type 2 diabetes mellitus.
The ability of peritoneal fluid to angiogenesis stimulation is probably one of the fundamental issues in pathogenesis of disease progression.
Therefore, the identification of the adaptation mechanism of this fungus to higher temperature is very important for efficient anti-fungal drug development as well as fundamental understanding of pathogenesis of A. fumigatus.
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