Despite this high level of insight, fundamental open questions remain, applying not only to SNARE protein domains but more generally to all types of membrane domains.
Physicists at the LHC are eagerly looking forward to establishing the true nature of the new boson and to the higher-energy running of the LHC, to find clues or answers to some of the other fundamental open questions in particle physics and cosmology.
The quest for a quantum version of general relativity addresses one of the most fundamental open questions in physics.
So the fundamental open questions about the unknown parts of genomes will greatly limit other approaches to understanding how even the simplest of cells work, and a couple of examples come to mind from my own research.
But whereas it can be shown by a standard diagonal argument that the arithmetic hierarchy does not collapse, the following are also currently unresolved questions of fundamental importance: Open Question 3 Is \ \textbf{PH}\) a proper hierarchy – i.e. is it the case that for all \ k\), \(\Sigma^P_{k} \subsetneq \Sigma^P_{k+1}\) and \(\Sigma^P_{k} \neq \Pi^P_{k}\)?
A fundamental and open question is whether monkeys can reason about symbols in ways similar to how they reason about real objects.
In fact, the following is another fundamental unresolved question in contemporary complexity theory: Open Question 2 Are the classes \ \textbf{NP}\) and \ \textbf{coNP}\) distinct?
Using a composite gene-set analysis method (ADGO) [ 9, 10], we combined the information of TF binding site (TFBS), Gene Ontology or KEGG pathway gene sets, and the gene expression fold-change profiles, and thereby tried to address the fundamental but largely open question of which TFs regulate which functions or pathways under differing cell conditions?
Indisputably, the main and important down side of working with multiple choice based surveys is the loss of the fundamental benefit of an open question that allows the respondent to freely and unlimitedly elaborate on each specificity of its criminal justice system and go into every exception.
Whether scale-free networks are directly selected for being evolvable, error tolerant or robust, or whether the scale-free topology emerges out of more fundamental processes remains an open question.
