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This discovery sparked intensive experimental and theoretical interests, both for its fundamental novel electronics properties as well as possible applications in a new generation of electric devices.
These fundamental novel findings show that the tight coupling between the frequency of Ca2+ oscillation and phasic contraction of the myocytes in the vessel wall regulates arteriolar diameter in situ.
14– 17 LCO ligands have proved useful for gaining fundamental novel insights regarding the structural heterogeneity reported for infectious prions as well as Aβ aggregates, 7, 8 and optical identification of protein aggregates with distinct topologies are highly important.
Regardless of this, a hardly debatable fundamental novel characteristic of the last eukaryotic common ancestor was the ability to exploit prokaryotic biomass by the ingestion of entire cells, i.e. phagocytosis.
The present study provides fundamental novel mechanistic insights into how PINK1 activates Parkin E3 ligase activity and suggests a dual regulatory mechanism of Parkin E3 ligase activity in which PINK1-dependent phosphorylation of Parkin at Ser is required to prime Parkin for activation by ubiquitinPhospho−Ser65. [γ-P]ATP was from PerkinElmer.
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Yet, the article provides no fundamental or novel mechanistical insights, and even the central idea of using cell-cycle arresting chemicals is not conceptually novel.
And its fundamental design — novel wings with engine "pods" positioned underneath — became the standard for almost all commercial jet carriers.
These important players could be fundamental in novel immune modulation approaches to improve host response to vaccination or antibiotic therapy.
This initial agnosticism as to the ability of the network approach to reveal fundamental and novel biological principles has hardened into a deep skepticism regarding its very relevance [ 8].
Instead, it is a novel, fundamental type of property altogether.
Fig. 1 Fundamental basis for novel approaches in dental repair.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com