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Therefore, evolutionary development does not merely extend forward from unicellular roots, but remains anchored to those fundamental linkages in perpetuity [52] as the stage in which the eukaryotic entity recenters the information that it will use for its next macro elaboration.
(19) However, it was not fully clarified whether there were fundamental linkages between HGF/c-MET signaling activation and resistance to the cytotoxic anticancer drugs.
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These methods do not readily reproduce gene expression networks but are more focused on the fundamental linkage between pairs of genes.
Antigenic and epidemiological dynamics show a fundamental linkage so that large jumps of antigenic phenotype result in increased rates of infection.
The fundamental linkage of diurnal changes to the light cycle is evident for photosynthetic organisms, but day night cycles also determine the timing for food access in animals, and associated activities entrain susceptibility to environmental hazards and predation.
The clinical features of GTNI, its infiltrative growth characteristics, typically dominating astroglial components, and frequent p53 expression, are all consistent with a fundamental linkage to the diffuse astrocytic tumor group.
Development of molecular markers such as SSR (simple sequence repeat), DArT (diversity arrays technology) and SNP (single nucleotide polymorphism) is fundamental for linkage map construction and QTL mapping.
To find applicable solutions, dynamic balance can be considered in the very beginning of the design process by synthesis from principal vector linkages: fundamental kinematic architectures with inherent force balance.
However, linkage disequilibrium (LD) between tightly linked SNPs violates the fundamental assumption of linkage equilibrium (LE) between markers that underlies most multipoint calculation algorithms currently available, and this leads to inflated affected-relative-pair allele-sharing statistics when founders' multilocus genotypes are unknown.
In general, the so-called CBR [1, 2] is viewed as the fundamental assumption for linkage between the deformation descriptions of crystal configurations and the continuum theories of crystal mechanics.
The analysis of chromosomal regions that are identical by descent is a fundamental tool in linkage analysis of pedigree data and in population genetics studies such as genome-wide association studies (Browning and Browning, 2010).
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