The traditional separation between subdisciplines is a fundamental limitation that needs to be overcome if complex processes, like oncogenesis, are to be understood.
This work provides a compelling argument that the traditional separation between medicine and evolutionary ecology remains a fundamental limitation that needs to be overcome if complex processes, such as oncogenesis, are to be completely understood.
All three objectives are better achieved with high values of the neutron multiplication factor (k-eff) with the obvious and fundamental limitation that it cannot reach criticality under any event, particularly, in the case of a loss of coolant accident.
Although many extensions of Mie theory have been made for covering different aspects including magnetic and coated spheres [29, 30], this analytical method has a fundamental limitation that the exact solutions are restricted only to highly symmetric particles such as spheres and spheroids.
Aside from having lower ecological validity, there is a fundamental limitation that stems from the stimulus presentation constraints in ERP attention paradigms.
These activities are recognized as having the fundamental limitation that they are unlikely to be well enough resourced to provide specialised assistance to all, or even a high percentage, of clinical episodes.
The expansion of functionality by duplicating genes to fine-tune spatial-temporal expression, without altering the properties of the ligands so that they can be distinguished by the signaling receptors or other binding proteins, does impose the fundamental limitation that the isoforms can only achieve their distinct functions without overlap in their expression patterns.
However, FRET has a fundamental limitation that it only occurs over rather short distance of several nm between the donor and the acceptor fluorophores, depending on Förster distance R0, which is determined a priori by the dye combination used [ 19, 20].
But despite our sense of optimism emerging from the contextual case and the success stories revealed in the literature, our project is not unaware of key challenges and 'fundamental' limitations that have a potential to impact its successful implementation.
