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The ability to probe complex environments at the sub-diffraction size scale has proven invaluable in revealing fundamental heterogeneity and improving overall understanding across the applied physical sciences.
In 2003, Vieland and Huang, on the basis of a "fundamental heterogeneity equation," proved that heterogeneity and epistasis are confounded in ASP linkage analysis.
And given the fundamental heterogeneity of social life, the choice of scale makes a big difference to the findings.
Countering legendary representations of the émigré as a nostalgic and decadent aristocrat doggedly attached to ancien régime life, this book is at its best when it illustrates the fundamental heterogeneity of the French émigrés.
When differences in behaviors are observed for different stem cells in different miniwells, one cannot discern whether these represent stochastic changes, or are the product of subtle differences in microenvironmental signals, or reflect a fundamental heterogeneity of the stem cell population.
The answer to this question has clear implications for the design of molecular targeted therapies, as well as for managing the fundamental heterogeneity of breast cancer.
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The underlying heterogeneity within cells is a fundamental property of cellular systems for homeostasis and development [3].
Still, fundamental racial heterogeneity in a student body sets the stage for engagement with diversity and difference during college, which is linked to a range of educational and civic benefits.
Notably, next-generation sequencing technologies are providing vast arrays of biological data, and phylogenetics will have to deal with very large multigene or genomic data sets making the understanding of model-fit heterogeneity fundamental.
In many cases, CTCs are present prior to treatment but their numbers can be limited, due in part to previous chemotherapeutic treatment or the fundamental patient-to-patient heterogeneity of tumor behavior.
However, spatial and temporal intra-tumoral heterogeneity pose fundamental challenges to representative sampling and consequently the feasibility of a personalized medicine approach.
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CEO of Professional Science Editing for Scientists @ prosciediting.com