Sentence examples for fundamental hallmarks from inspiring English sources
Genetic somatic alterations are fundamental hallmarks of cancer.
The fundamental hallmarks of systematic form, according to Reinhold, are consistency and completeness, but it was the former of these that attracted most of Reinhold's attention.
Other fundamental hallmarks of epithelial carcinogenesis include an elevated intracellular pH (pHi) as well as their increased rate of glucose utilization over oxidative phosphorylation [2], [3].
Epigenetic modifications are currently considered as fundamental hallmarks of human cancer, playing a pivotal role in tumorigenesis [ 97].
Disabled apoptosis has been catalogued among the fundamental hallmarks of cancer and the proteins of the Bcl-2 family play a fundamental role in regulating this modality of cell death.
Despite the fact that alterations to the physiological cellular responses to environmental cues are fundamental hallmarks of cancer cells (Hanahan and Weinberg, 2000) and that cellular responses to input cues are driven by signaling networks, a comprehensive understanding of how mutations perturb these networks is still missing.
The fundamental hallmark of an equilibrium process is reversibility.
This metabolic shift termed Warburg effect is now considered a fundamental hallmark of cancer.
Hormone dependence is a fundamental hallmark of the majority of breast cancers, and tumour growth can be inhibited either by deprivation of circulating oestrogens or by antagonising the effect of these hormones on their receptors [ 1].
Female and male gametophyte development differ considerably, but at the same time share the same fundamental hallmark of being haploid organs: it is therefore logical that they might require the same basal machinery and share a number of common regulators [ 5].
The reliance of tumor cells on glycolysis even in aerobic conditions is termed the "Warburg effect", a fundamental hallmark of cancer associated with aggressive disease and poor prognosis, and adipose tissue-mediated induction of this pathway in tumor cells indicates a mechanism by which obesity promotes cancer mortality.
