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In conclusion, using two different cell culture models of aberrant MYCN expression, we have defined a fundamental gene expression profile that is less subject to many of the common experimental variables.
These regulatory pathways have been widely found in multiple biological processes and are considered to be one of the most fundamental gene expression regulatory mechanisms in biological systems [17].
However, the mechanisms cells utilize to sense and respond to microgravity and the fundamental gene expression changes that occur are largely unknown.
This study provided fundamental gene expression data that will help to understand molecular mechanisms of diurnal and seasonal adaptation in conifers.
Because TH also tightly regulates fundamental gene expression both directly and indirectly, not only in the cerebellum but also in other brain regions (Koibuchi et al. 1999, 2001), the inhibitory effects of PBDEs on TR-mediated gene expression may widely disrupt normal brain development via TH-dependent gene regulations.
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Holter et al. [ 14] employ singular value decomposition to uncover the fundamental patterns underlying gene expression profiles.
Protein synthesis (or translation) in eukaryotic cells is fundamental for gene expression and is tightly controlled by three fundamental stages: translation, elongation, and termination [24], [36], [37].
Of course, in reality there are many more functional types of noncoding RNAs than just these four aside for the fundamental for gene expression tRNAs and rRNAs, the snRNAs (small nuclear RNA, components of the spliceosome) and snoRNAs (small nucleolar RNAs that guide the chemical modifications of other RNAs) are also large classes of noncoding RNAs that have been known for decades.
Protein synthesis (or translation) in eukaryotic cells is fundamental for gene expression and is mainly regulated at the initiation step.
Making the correct choice between transcription elongation and transcription termination is essential to the function of RNA polymerase II, and fundamental to gene expression.
A fundamental MYC gene expression profile may be broadly relevant to different types of MYC-driven tumors and should facilitate elucidation of the complex cellular responses that mediate the biological activities of the MYC protein.
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