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Neuronal differentiation is an early and fundamental event in neurodevelopment.
The fundamental event in prion diseases seems to be a conformational change in cellular prion protein (PrPC) whereby it is converted into the pathologic isoform PrPSc.
The fundamental event in EMT is the repression of epithelial cadherin (E-cadherin), which is responsible for maintaining adherens junctions and cell-cell adhesion.
The loss of E-cadherin expression is a critical and fundamental event in EMT, and many inducers of this process act directly or indirectly by repressing E-cadherin expression [6], [11], [13] [19].
E-cadherin loss is considered to be a fundamental event in the EMT process.
Accumulation of hemoglobin in differentiating erythroid progenitor cells is a fundamental event in normal erythropoiesis.
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The results reported here illustrate a rare example of connection between fundamental events in molecular evolution.
u-PAR regulates pericellular proteolysis and cell surface adhesion receptors, fundamental events in the first steps of invasion and angiogenesis.
Disturbances of proliferation and apoptosis are fundamental events in early carcinogenesis, and may be useful in characterizing tissue that is histologically normal but at high-risk for neoplastic growth.
Instead, we focus on emerging findings regarding the interactions of the latter signalling pathways with mitochondria, an organelle increasingly recognized as not only a power station, but also as a signalling platform involved in fundamental events in the formation and plasticity of neuronal circuits.
The most fundamental event occurring in this consciousness is the creation of time awareness through the acts of protention (future) and retention (past), which is something like a self-constitution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com