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MicroRNAs (miRNA) are now recognized as fundamental effectors of posttranscriptional gene expression control.
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Such observations would suggest TAZ as a fundamental effector of the Wnt signaling pathway.
Caspases are key effectors of apoptosis.
Caspases are central effectors of apoptosis [ 24].
We conclude that a better understanding of the pharmacology of these receptors, especially in chronic inflammatory settings, could guide innovative drug discovery programs aimed at capitalizing the fundamental actions of these effectors of resolution.
In melanoma, several models of resistance to TGF-β growth suppressor signals have been suggested, also in view of the dysregulation of fundamental cellular effectors and signaling pathways [9, 22].
Rho/Rac GTPases are effectors of cell surface receptors that control fundamental cellular functions, including actin cytoskeleton dynamics, cell morphology, motility, and the progression through the cell cycle [ 1].
Protein synthesis is a fundamental cell process and ribosomes - particularly through the ribosomal RNA that display ribozyme activity - are the main effectors of this process.
Many cellular effectors of pluripotency are dynamically regulated.
While the functions and effectors of the closely related Arf proteins have been extensively characterised, much less is known about Arl protein interactions and their regulation of fundamental processes within the eukaryotic cell.
Downstream effectors of Id-1 were identified.
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