Our in-silico analysis of the mirBase targets database [27] was directed towards identification of miRNAs potentially targeting HES1, an effector of the Notch pathway, a fundamental mechanism in the regulation of MB cell proliferation.
Together, our findings implicate MMP14 as a downstream effector of VANGL2 signaling and suggest a model whereby the regulation of pericellular proteolysis is a fundamental aspect of PCP in migrating cells.
In melanoma, several models of resistance to TGF-β growth suppressor signals have been suggested, also in view of the dysregulation of fundamental cellular effectors and signaling pathways [9, 22].
Nusse R. "A versatile transcriptional effector of Wingless signaling". Cell.
We conclude that a better understanding of the pharmacology of these receptors, especially in chronic inflammatory settings, could guide innovative drug discovery programs aimed at capitalizing the fundamental actions of these effectors of resolution.
The upregulation of Spry1, PTEN and Pdcd4 was observed in miR-21−/− keratinocytes, which is associated with reduced activation of the major downstream effectors of RAS signalling, which is fundamental for skin carcinogenesis initiation.
Rho/Rac GTPases are effectors of cell surface receptors that control fundamental cellular functions, including actin cytoskeleton dynamics, cell morphology, motility, and the progression through the cell cycle [ 1].
Protein synthesis is a fundamental cell process and ribosomes - particularly through the ribosomal RNA that display ribozyme activity - are the main effectors of this process.
