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The fundamental drawback of "Nightingale," directed by Joseph Hardy, is the off-putting persona of the woman Ms. Redgrave has conjured.
However, BOINC suffers from the fundamental drawback of overloading the server because it follows a master/worker model, in which a central entity is responsible for scheduling and validating tasks.
A fundamental drawback of much of the research so far is that the people studied have been asked to rate their own popularity in the eyes of others, which naturally brings those scores into question.
Moreover, one fundamental drawback of stereo based reconstruction of 3D shapes is that the reconstructed entities' precision decreases quickly with distance to the cameras, due to the images' finite pixel sampling [49], [50].
A method to overcome this fundamental drawback of typical modularity optimization was put forth in [ 16].
Moreover, the fundamental drawback of this model is that surgical occlusion of arteries is not the cause of the human disease (McCarthy et al., 2011b).
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In the Soviet Union itself, a debate concerning the most appropriate means for implementing plans went on for some years, but, despite numerous efforts on the part of the government to reorganize the machinery of planning, the fundamental drawbacks of central economic planning were never overcome.
For many supporters of affirmative action, there is another, more fundamental, drawback: the programs don't sufficiently lift the number of minority students in undergraduate programs -- and do virtually nothing for graduate schools.
Among other factors, this fundamental drawback has resulted in the cancelled deployment of these reactors.
However, direct inkjet printing of nanoparticle or nanowires has a fundamental drawback in inkjet nozzle clogging and limited ink choice in concentration and viscosity.
In addition, using single photons to build encryption keys has one fundamental drawback: distance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com