'fundamental drawback' is correct and usable in written English.
You could use it to point out a key issue or concern with something. For example: "The fundamental drawback to this plan is the difficulty of implementation."
The fundamental drawback of "Nightingale," directed by Joseph Hardy, is the off-putting persona of the woman Ms. Redgrave has conjured.
For many supporters of affirmative action, there is another, more fundamental, drawback: the programs don't sufficiently lift the number of minority students in undergraduate programs -- and do virtually nothing for graduate schools.
In addition, using single photons to build encryption keys has one fundamental drawback: distance.
Among other factors, this fundamental drawback has resulted in the cancelled deployment of these reactors.
Among the existing candidates to overcome this fundamental drawback, the F2Be-molten-salt, has proved to feature outstanding neutronic properties.
However, direct inkjet printing of nanoparticle or nanowires has a fundamental drawback in inkjet nozzle clogging and limited ink choice in concentration and viscosity.
In the Soviet Union itself, a debate concerning the most appropriate means for implementing plans went on for some years, but, despite numerous efforts on the part of the government to reorganize the machinery of planning, the fundamental drawbacks of central economic planning were never overcome.
Although this may be regarded as a reasonable choice, it has two fundamental drawbacks.
Traditional atomistic simulation methods and classical continuum approaches have their own fundamental drawbacks in dealing with this large atomic system.
The network mobility protocol based on Mobile IPv6 as proposed by the Internet Engineering Task Force (IETF) in 2005 has some fundamental drawbacks, such as header overhead and the pinball problem.
The revision of the conventional Magnitude Optimum design criterion for tuning the PID type controller's parameters reveals three fundamental drawbacks.
