However, there is one fundamental difference compared with the treatment of an infectious disease: Only lead removal from the environment, not the medical treatment of an individual, will reduce the risk to others in contaminated environments.
There is also the anticipated barrier for children and their families to use atropine in the European population due to less acute awareness of myopic-related ocular complications and fundamental cultural differences, compared to the Asian populations.
Although adult cells, such as chondrocytes and mesenchymal stem cells, show fundamental biological differences compared to embryonic stem cells, including their limited potential to self-renew, they have been shown to be capable of greater plasticity than previously expected and to retain their potential to undergo chondrogenesis following considerable expansion in vitro [ 27, 41- 44].
Besides its exceptional accuracy, the fundamental differences as compared with the 454-pyrosequencing approach are the extremely high throughput of the SOLiD system (200 Gb/run) and the short-read technology (50 75 nucleotides/read).
There are several differences compared with HOTOL.
A compound which is cytotoxic can be so via multiple mechanisms - a fundamental difference when comparing with single endpoint toxic mechanisms like hERG or P450 inhibition [17].
The heterogeneity may introduce fundamental differences into the dynamics, compared to the homogeneous case.
Theoretical limitations of the study are a) documentation of pulmonary shunt by means of pulmonary catheterization was not implemented in the study design, b) fundamental differences of tetrapod vertebrates compared to humans regarding prone or supine position in lung injury models have not been described in literature.
However, there are some fundamental differences in Lou/C rats compared with αMUPA mice, such as increased levels of PGC-1α and SIRT1 in the liver, increased levels of ghrelin, and reduced levels of leptin and insulin in the serum, although with some improved sensitivity for the latter two hormones [ 251, 252].Overall, it seems that αMUPA mice are metabolically different from Lou/C rats.
