Sentence examples for fundamental defect of from inspiring English sources

"Berlusconi says yes to everything and then Tremonti [the finance minister] says no," says another former cabinet minister, who thinks Mr Berlusconi has damaged Italy but nevertheless describes him as "charming, magnetic, one of the most intelligent people I have met".The fundamental defect of Mr Berlusconi's governing style is that he often confuses private interests with public ones.

Therefore, there has been a search for new agents that would address fundamental defects of type 2 diabetes and have minimal adverse effects.

32 The fundamental defect is of normal ciliary motility, which, for the laterality defect, is in the nodal region of the embryo.

The lack of response may reflect a fundamental defect in the proposed mechanism of action or inadequacy of exposure (dose), frequency, or timing of the investigational drug.

In this letter he wrote, "The fundamental defect is a want of power in Congress…the confederation itself is defective and requires to be altered; it is neither fit for war, nor peace".

I think that even he would concede that there are occasionally bad apples in the dog world — dogs that are the way they are because of some fundamental defect — the same way the human world occasionally gives us a Jeffrey Dahmer.

First, it has been suggested that dysfunctional β-cells present a fundamental defect in the pathway responsible for processing of proinsulin to insulin (18).

An alternative method to address the fundamental defect in cystic fibrosis is the development of genotype-specific small-molecule drugs that modulate CFTR function.

BRCA1 and BRCA2 germline mutations are the fundamental defect in hereditary OC where the normal allele of the carrier is inactivated in cancer cells [ 66, 67].

This clinical observation confirms the logic of targeting CFTR to treat the fundamental defect in cystic fibrosis and makes it a highly attractive strategy [ 5].

The fundamental defect in lipid metabolism in patients with type 2 diabetes is the hepatic overproduction of large VLDL particles, particularly VLDL1 (38).