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The fundamental challenges are to describe, analyze, simulate and predict the dynamics of life processes.
To mimic the human brain, the fundamental challenges are the replication of the time-dependent plasticity of synapses and the achievement of the high connectivity in biological neuron networks, where the ratio between synapses and neurons is around 104.
The concept of variable stiffness elements based on antagonistic forces (prestress) in cable-driven mechanisms is presented and the fundamental challenges are identified and addressed including: (1) the relative significance of the antagonistic stiffness versus the structural stiffness, and (2) the extent of the antagonistic stiffness.
The evidence is compelling and timely, demonstrating as it does that Roma social inclusion policies in Europe cannot be effective unless fundamental challenges are addressed.
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But fundamental challenges were confronting television.
"One of our fundamental challenges is making sure that leaders are recognised as part of the community that they are serving; we need leaders at all levels and organisations that are connected.
"One of the Internet's fundamental challenges is its inability to effectively capture the economic value it creates for business in the physical world," notes Braccia.
One of the fundamental challenges is the development of digital geometry-centric engineering representations that are self describing and assured to be interpretable over the long lifespans required by archival applications.
One of the fundamental challenges is to efficiently support a wide range of traffic patterns, and thus emerges the need for equipment that is both practical and economical to construct and deploy.
One of the fundamental challenges is to produce functionally active enzyme in H. polymorpha.
The fundamental challenges were the same for both groups and for all three scales of production.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com