Benzimidazole is a privileged pharmacophore encountered in a number of fundamental cellular components and bioactive molecules.
In the cellular component category, several key cellular components were identified, such as cell part, membrane and ribosome.
In summary, the level of complexity of signaling systems involved in cognitive systems stems from the functions of components as fundamental cellular roles.
Identifying protein complexes from protein-protein interaction network is fundamental for understanding the mechanism of cellular component and protein function.
The highly conserved SR protein kinase 1, SRPK1 [23], was shown to play an important role in the regulation of some fundamental cellular processes, including the organisation of components of the nucleus and mRNA processing.
Collagen is an important extracellular matrix component that directs many fundamental cellular processes including differentiation, proliferation and motility.
Bacteria have evolved complex, multi-component cellular machineries to carry out fundamental cellular processes such as cell division/separation, locomotion, protein secretion, DNA transcription/replication, or conjugation/competence.
Microtubules are one of the major cytoskeletal components of neurons, essential for many fundamental cellular and developmental processes, such as neuronal migration, polarity, and differentiation.
Protein kinases are a major component of the complex signalling networks that coordinate all fundamental cellular processes, including transcription, cell cycle and metabolism.
While stress-activated kinases and ROS generation have been identified as downstream components of the cardiomyocyte response to human AL-LC, the fundamental cellular mechanisms underlying the proteotoxicity remain elusive.
