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Here, we have circumvented these issues by profiling uniform cultures of primary malignant stem cell lines that can reconstitute the tumor in vivo [ 6], in direct comparison to normal counterparts of the same fundamental cell type [ 4, 5].
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Studies of isolated myocytes or myocardial tissue preparations may therefore lack fundamental cell types that are necessary for the genesis of EADs.
The uniquely high expression of TIMAP protein in endothelial cells [ 3] implies its significance in fundamental activities of this cell type.
Though comparatively sparse, in vivo studies consistently show that these fundamental processes vary from cell type to cell type in animals, but the factors controlling such cell type-specific modifications remain for the most part poorly defined.
It is not yet clear whether congenital and acquired melanocytic naevus (AMN) cells develop from the same cell type; however, fundamental similarities between naevus cells suggest that they may.
Understanding the regulation of the RdCVFs is not only important for what it can teach us about fundamental questions of cell type-specific gene transcription and processing, but also because manipulating expression of members of the RdCVF family could have therapeutic potential.
The manner in which genes are regulated to produce the correct combination of proteins for every cell type remains a fundamental question in biology.
Moreover, fundamental cell biological studies are needed to identify the optimal cell types, and to develop strategies that may enhance homing, survival and effectiveness of the injected cells.
A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth.
A fundamental problem in cancer research is identifying the cell type that is capable of sustaining neoplastic growth and its origin from normal tissue cells.
Based on the data presented here we speculate that cell type specific factors play a fundamental role in RANTES expression.
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