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"fundamental breakthrough" is a correct and commonly used phrase in written English.
It refers to an important and significant advancement or discovery in a particular field or discipline. It is typically used to describe a major achievement or breakthrough that has a significant impact on the way something is understood or done. Examples: 1. The scientist's research led to a fundamental breakthrough in the understanding of human genetics. 2. The new technology has the potential to be a fundamental breakthrough in the healthcare industry, revolutionizing the way we diagnose and treat diseases. 3. The team's tireless efforts have finally resulted in a fundamental breakthrough in renewable energy, making it more accessible and affordable for all. 4. After years of experimentation and hard work, the artist's latest painting represents a fundamental breakthrough in their style and technique. 5. The collaboration between these two renowned universities has resulted in a fundamental breakthrough in the field of artificial intelligence.
Exact(22)
But it also represents a fundamental breakthrough in the shape of the global climate regime.
In Ireland, one industry researcher made a fundamental breakthrough in science.
The deal "marks a fundamental breakthrough in foreign investors' belief in Russian companies," Mr. Fridman said.
But Smolin, after meeting Lisi and talking to him, became convinced that it was at least possible that Lisi had made a fundamental breakthrough.
On the borderline with mathematical physics but clearly on the mathematical side came a fundamental breakthrough in the quantum mechanics of many-particle systems.
Neither in Beijing nor Rome is there any sense that the new bishop's elevation to lead the capital's most prominent parish was a fundamental breakthrough.
Similar(36)
What can create better incentives for fundamental breakthroughs than bounding innovation with planetary boundaries?
The rationale is sound: it takes fundamental breakthroughs to make a real difference in medicine.
The more clinically focused applications tend to lead to quicker but less fundamental breakthroughs.
This treaty ignores the fundamental breakthroughs and technology during the last 30 years.
Under the heading of "advancing ideas", Wellcome will continue to fund fundamental breakthroughs in biomedicine and health.
More suggestions(15)
vital breakthrough
main breakthrough
major breakthrough
central breakthrough
substantial breakthrough
fundamental achievement
essential breakthrough
seminal breakthrough
fundamental turnaround
fundamental revelation
fundamental milestone
substantive breakthrough
basic breakthrough
significant breakthrough
fundamental leap
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com