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A fundamental bottleneck has been the performance — how many applications are there that can run on a database that can just do 5 transactions per seconds".
"It's their recognition that the lack of training data is a fundamental bottleneck to the adoption of AutoML," he told me.
This turns to be a fundamental bottleneck when it comes to design automation using numerical optimization techniques.
It has been intuited that calculated energies from physics-based scoring functions are able to distinguish native from nonnative folds based on previous performance with small proteins and that conformational sampling is the fundamental bottleneck to successful folding.
Nonetheless, our study here supports the general feasibility of a highly-parallel functional analysis of candidate cancer genes, addressing a fundamental bottleneck in the annotation of cancer genomes.
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But some fundamental bottlenecks need to be sorted out soon.
The proposed immune procedure is built on the following fundamental idea: the bottleneck jobs existing in each scheduling instance generally constitute the key factors in the attempt to improve the quality of final schedules, and thus, the sequencing of these jobs needs more intensive optimization.
Continued work in this area has the potential to paint a clearer picture of the fundamental mechanisms driving key industrial bottlenecks and may lead to cost-effective methods for circumventing them.
While there is great expectation and an understandable emphasis on translational research in many quarters, we believe that the challenges in understanding fundamental epigenetics and chromatin processes remain bottlenecks in achieving these goals.
These fundamental differences suggest very different mechanisms and/or bottlenecks are driving dispersal and evolution in chemotrophic vs. phototrophic communities.
Motivation: The exponential growth of protein sequence databases has increasingly made the fundamental question of searching for homologs a computational bottleneck.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com