Sentence examples for fundamental abnormalities in from inspiring English sources

Many inflammatory processes participate in the pathogenesis of RA, and autoimmune responses are considered fundamental abnormalities in RA [ 1].

Taken together, no fundamental abnormalities in the embryonic development of Tfap2e−/− mice became apparent in these experiments.

This characteristic is often used to quantify tetrapyrroles for the diagnosis of porphyrias (a group of diseases that have fundamental abnormalities in the heme biosynthetic pathway in common) (Polo et al. 1988).

The fundamental abnormality in glucose metabolism underlying these disorders is insulin resistance [ 2].

Alternatively, a fundamental abnormality in processing external sensory stimuli may contribute to a negative sense of self in BPD.

BHR is a fundamental abnormality in asthma which increases in proportion to disease severity and is functionally antagonized by β2-adrenoceptor agonists.

However, several series have documented symptoms that might signify a more fundamental abnormality in coding somatosensory signals, in particular pain and temperature, by patients with FTLD (Bathgate et al., 2001; Snowden et al., 2001; Ahmed et al., 2015).

Indeed, Idh1 KO hepatocytes showed increased levels of ROS compared with WT hepatocytes as measured by the CM-H2DCFDA (DCFDA) assay, indicating a fundamental abnormality in the oxidative stress response in these mutant cells, which is not limited to states of inflammation.

Although it is clear that TCZ treatment led to improvements in markers related to systemic inflammation and bone and cartilage metabolisms [ 87– 89], it remains to be determined whether the treatment can correct fundamental immunological abnormalities in RA [ 90].

Gene microarrays, plasma S100 protein levels, and single-cell auto fluorescence support the hypothesis that there is a fundamental activation abnormality in neutrophils of children with polyarticular JRA.

The present data show that arginine metabolism is disrupted in a proportion of GBM, further emphasizing that abnormalities in fundamental metabolic pathways are a major feature of this disease.