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Among the three Sestrin homologues in mammals (Sestrin1 3), we recently found that, through unknown mechanisms, Sestrin2 expression in the liver becomes elevated upon hypernutrition and obesity and functions to alleviate insulin resistance and hepatosteatosis12.
Thus, our in vitro and in vivo findings support the exploration of stimulating rather than suppressive therapies with the potential to more specifically reprogram monocytes toward immunoregulatory functions to alleviate chronic CD.
Chd1 functions to alleviate the nucleosomal barrier to PolII transit at highly processive genes.
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This social connection functioned to alleviate uncertainty about the female entrepreneur.
Many range-free schemes focused on solving the problem to define this function to alleviate distance errors (e.g., [11, 12]).
For example, Zhang and Yan devise an effective convolutional neural network to estimate air's quality based on photos by a modified activation function to alleviate the vanishing gradient issue [43].
Valproate (VPA) is a widely used treatment agent against seizures and bipolar disorder, and its function to alleviate damage due to migraine has also been verified in clinical investigations.
As described in the next section, we propose an improved Markov random field (MRF) approach, which involves both local and long-range information in a simpler energy function, to alleviate the aforementioned limitations of our previous work [1].
The observed up-regulation of stress and CYP genes may thus function to alleviate immunity-related self-damage.
Instead, it may function to alleviate the steric forces at the inner-bending side of the kink.
However, patients and their caregivers also explained their ongoing khat use was necessary to improve the patient's functioning and to alleviate medication side effects [ 19].
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