In essence, host phenotypes are used as probes to gauge and manipulate those microbiome functions that impact host fitness.
The compound 5-HTP has effects on both sleep and mood, as well as other body functions that impact our health and our ability to feel good during the day and sleep restfully at night.
In this context, several mammalian SIRTs have functions that impact on aging-associated molecular pathways and disease [ 9, 10].
The unique feature of MSCs is their array of immunoregulators, which collectively mediate the immunosuppressive and regenerative functions that impact the clinical outcome.
The effect is most readily observed when pUL135 is expressed in isolation, given that HCMV encodes additional functions that impact on actin (Seo et al., 2011) and adhesion junctions (Stanton et al., 2007).
A popular strategy to mitigate this has been to decrease culture temperature, but many cellular functions that impact yield (e.g. transcription, translation, folding rates, membrane composition) are also affected by low temperature stress [ 28], which means that yield increases do not always transpire.
If they're not supporting the outside customer, they're serving an internal function that impacts the outside customer.
For this example, the negative weight on progeny inbreeding is the only component in the objective function that impacts the mate allocation part of the mate selection algorithm.
We thus ask whether there is a transcriptional regulation between NF-κB and STAT5 activation in MLCK-mediated IEC barrier function that impacts intestinal immune response to mucosal inflammation.
A further goal is to develop quantitative risk tools, such as vulnerability and fragility functions that relate impacts to the amount and characteristics of ashfall received and to develop more quantitative relationships for use in risk modelling.
