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The top biological processes and metabolic functions that are enriched in the set are shown in Figure 3.
It is possible that these uncharacterized genes also have the functions that are enriched in the module.
The top clusters of biological processes and metabolic functions that are enriched in the set of differentially expressed genes are shown in Figure 5B.
To determine the target biological pathways for each small molecule, we developed a novel framework for encoding small molecule effects on a spectra of biological processes or GO functions that are enriched in the differentially expressed genes of a given small molecule perturbation.
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On the basis of the biological functions that were enriched in the regulated gene list, the software proposes the diseases where these biological functions may be affected.
We performed Fisher's exact test on GO terms to identify gene functions that are enriched in VMN or H.
To identify biological functions and diseases that were enriched in the different datasets, genes were associated with biological functions and/or diseases in the Ingenuity Knowledge Base.
Interestingly, the positive genes that are enriched in both the histone marks are highly enriched in the categories of tissue specific cellular functions, such as endocrine system disorders, gastrointestinal disease.
Nodes of the cellular interactome that are enriched in immune functions also reconstitute sub-networks.
We identified 742 neuron-restrictive silencer elements (NRSE) associated with 1396 genes that are enriched in neuronal function.
Nevertheless, the ChIN had hubs that were enriched in key cellular functions.
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