It engages in a complex interaction with another part of the brain, the globus pallidus, which is involved in functions such as the regulation of voluntary movement.
This circuit is crucial for many important functions, such as the regulation of voluntary movement, and is also involved in human neurodegenerative and neuropsychiatric disorders.
Similar to previous studies, there are transcriptional regulatory related functions, such as the regulation of three RNA polymerase promoters, transcription anti-termination, and histone deubiquitination.
It is reported that microRNAs are involved in physiological and pathological functions, such as the regulation of developmental timing and pattern formation [12], restriction of differentiation potential [13], chromatin rearrangements [14], and carcinogenesis [15].
In addition to wildtype MYCN, we studied a mutant MYCN with a deletion within MYC homology box II (MBII), a conserved region among MYC family members shown to be essential for many of MYC functions such as the regulation of some target genes, transformation, proliferation, and apoptosis [34], [39] [41].
Steroid hormones mediate various vital physiological functions, such as the regulation of metabolism and immune response.
Numerous other functions, such as regulation of intracellular vesicular pH, regulation of membrane recycling, and regulation of mucin exocytosis are less firmly established.
The sixth GO module mainly described cell death and apoptosis related functions, such as regulation of apoptotic process (GO: 0042981) and regulation of programmed cell death (GO: 0043067).
In contrast to the functions of the genes in cluster 4, the genes in cluster 1 presented distinct functions such as regulation of reactive oxygen species, response to interlukin-6, and regulation of the activation of JAK2 kinase activity.
Cellular functions such as regulation of transcription, DNA repair, cell cycle regulation, senescence and apoptosis are modulated by p53 as well as c-Jun.
One such function is light-dependent regulation of melatonin secretion, which is involved in various physiological functions such as regulation of locomotor activity and sleep [ 13, 14].
