The mesothelial cells play a major role in important physiologic functions such as dialysis, localization of infections and formation of abdominal adherences [7], [8].
The protein node is connected to a wide number of other nodes describing protein functions such as Transport, Localization, Modification and Metabolic.
After one day, there was a modulation of a great number of functions, from general processes such as metabolism to more specific functions such as development, localization and locomotion.
There are many examples of different isoforms of the same enzymic activity heterodimerizing to regulate localization and function, such as the myotubularins [ 26].
The spatial localization of genes and nuclear compartments within the nucleus affects cellular functions, such as regulation of gene expression, DNA replication and repair (Austin et al., 2010).
It was also reported that ER localization could alter the glycan structure of antibodies to an oligomannose-type of glycan structure, consequently influencing its function, such as the interaction between Fc regions and Fc receptor for antitumor activity [ 18].
The binding of PTEN to ATP not only controls nuclear localization, likely through the modulation of nuclear export, but also further regulates cellular functions such as abrogation of PTEN's tumor suppressor capabilities.
The deciphering of the underlying mechanisms of such apparently unexpected subcellular localization revealed that secreted factors and their receptors were internalized into the cytoplasm and routed to the nucleus, where they exert diverse functions such as regulation of gene transcription.
One potential explanation for such observations, as well as for the link between nuclear and cytoplasmic NOVA tags seen here, would be reassortment of transcripts in cis on individual transcripts, providing a means of linking nuclear functions such as alternative splicing with cytoplasmic function such as RNA localization or RNA stability.
Two strategies for data localization leading to optimal usage of cache memory are demonstrated to speed up certain cell-based functions (such as collision computations) by a factor of 3.38 4.36.
