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Threonine overproduction affects other cellular functions such as the accumulation of other amino acids, the cell growth and metabolite excretion, probably reflecting a redirection of the carbon flux in the central metabolism.
MATEs are secondary active transporters; in plants they have many physiological functions, such as the accumulation of secondary metabolites, aluminium detoxification and iron translocation (Takanashi et al. 2014; Jarzyniak and Jasinski 2014).
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Micropatterned substrates also provided short-range cues that influenced higher-order functions such as the localization of focal adhesions and accumulation of postsynaptic acetylcholine receptors.
Ghrelin has various physiological functions, such as the stimulation of growth hormone release and of appetite, and fat accumulation.
The insulin-like growth factor binding proteins (IGFBPs) have several functions, such as IGF transporting, accumulation of IGF at the specific cell pools, inhibition and activation of ligand receptor interaction.
Insulin has other critical functions such as reducing accumulation and oligomerization of amyloid β (10, 11), as well as reducing hyperphosphorylation of τ protein (12).
Autophagy mutants often exhibit phenotypes such as the accumulation of ubiquitinated protein aggregates, damaged organelles, increased sensitivity to oxidative stress, abnormal motor function, and short life span that are similar to those observed during ageing [ 172].
This exacerbates existing warming effects, such as the accumulation of greenhouse gases in the atmosphere.
In fact, pathological behaviours such as the accumulation of discontinuities may appear (Zeno phenomenon).
The stimulatory effects of FSH on Sertoli cell functions such as cAMP accumulation, protein kinase activation, and RNA and protein synthesis wane during testis maturation.
In addition, the wetland ceases to fill ecosystem functions, such as water table recharge and sediment accumulation.
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