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Specifically, whereas bacterial and chloroplast PNPase have demonstrated exoRNase and polyadenylation activities, hPNPase functions predominantly as an RNA importer39, showing exoRNase activity only in vitro42.
In contrast to hPR-A, which functions predominantly as a ligand-dependent transcriptional repressor, we show in this study that the A isoform of the chicken PR (cPR-A) lacks this trans-dominant repressor function and is a transcriptional activator in all contexts examined.
Copper is needed by the body for a number of functions, predominantly as a cofactor for a number of enzymes such as ceruloplasmin, cytochrome c oxidase, dopamine β-hydroxylase, superoxide dismutase and tyrosinase.
Our most recent study clarifies that ICP0 physically interacts with HSV's major transcriptional regulator, ICP4, and suggests that ICP0 influences whether ICP4 functions predominantly as an activator or a repressor of HSV mRNA synthesis [9].
Therefore, we propose that the accumulation of ICP0 in HSV-infected cells (or lack thereof) may dictate whether ICP4 functions predominantly as an activator, or a repressor, of HSV mRNA synthesis.
IGFBP7 has 30% homology to IGFBP1 to IGFBP6 in its N-terminal domain and functions predominantly as a tumor suppressor.
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The enzymes of subgroups 1 and 2 function predominantly as aromatic monooxygenases and the ones of groups 3-6 aliphatictic monooxygenases.
The lack of extenders for these pigments may infer that for W&N, extenders were primarily present to adjust physical properties, tinting strength or hue, rather than functioning predominantly as a means to reduce the cost of materials.
It was unknown whether the phage display generated sAB binders directed at the pointed end would all function predominantly as capping proteins or whether some would possess other properties.
Given the two recent studies that demonstrated that snoRNA can serve as miRNA precursor [6], [8], it is tempting to suggest that snoRNA HBII-85 and other similar "orphan" snoRNA function predominantly as processed small RNA species in miRNA and/or siRNA pathways [4].
Instead CX3CL1 was found to function predominantly as an adhesion molecule.
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