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However, miR-26a functions oppositely in osteogenic differentiation of BMSCs and ADSCs, suggesting distinct post-transcriptional regulation of tissue-specific MSC differentiation.
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Still the idea invites a worthwhile question: Is there anything human beings can produce that would function oppositely to mimetic poetry?
Notably, in different cell types, miR-195 may function oppositely.
In R. pedestris, however, RNAi of per and cyc induced distinct phenotypes both in the cuticle deposition rhythm and in the photoperiodic response, which suggests that the circadian clock itself, in which PER and CYC function oppositely, regulates not only the circadian rhythm but also the photoperiodic response.
Interestingly, mRNA levels of many genes involved in these functions were oppositely regulated by CDV in PHKs and in HaCaT cells or exclusively affected in one of the cell types.
Since the discovery of the relationship between Igf2 and Igf2r there have been no other clear examples of imprinted genes with antagonistic growth functions, although oppositely imprinted transcripts at the Gnas locus have antagonistic roles in behaviour and physiology [ 34].
The Reg+ function (Reg+ = 1 – Reg–) behaves oppositely.
This hypothesis suggests that estrogen has beneficial effects on neurological function if neurons are intact; however, oppositely, if neurological health has already been compromised, estrogen may exacerbate neurological impairment.
Based on the accumulated evidence we propose that Grb10 and Dlk1 may define a mammalian growth-regulatory axis that is separate from the IGF pathway, yet is similar in having as key components a pair of oppositely imprinted genes with antagonistic functions.
Patients with heart failure enrolled in the EPCOT Trial exhibited a marginal, sometimes oppositely directed change in platelet function, challenging the diagnostic utility of these platelet parameters and biomarkers to serve as useful tools for the identification of platelet abnormalities, for predicting clinical outcomes, or for monitoring antiplatelet strategies in this population.
It was found that Al3Sc and Al3Zr behave similarly, with increasing critical radii and decreasing misfit as a function of temperature, while Al3Ti and Al3Nb behaved oppositely.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com