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The functions of transposons remain unclear.
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The efficiency of Himar1 transposition is a function of transposon size, with a 38% decrease for every 1-kb increase in transposon size [ 23].
This newly identified active MITE, mGing, provides new insights into the function and significance of transposons in rice genome.
piRNAs were first shown to function in post-transcriptional regulation of transposons.
One such function could be the regulation of transposons, as 6mA appeared enriched in transposon regions and transposons marked with 6mA were derepressed in DMAD mutants.
In D. melanogaster the Piwi-interacting RNAs (piRNAs) appear to function primarily in the regulation of transposons in both the germ line and in somatic tissues that envelope the ovaries although it is clear that transposons are not the only genomic targets of piRNAs [ 9- 13].
In global genomic packaging, for all types of cells, DNA methylation may be a key component of repressive chromatin which functions to give long-term silencing of transposons, stabilization of silenced genes in the processes of imprinting and x-inactivation [ 17].
We report here the results of two genetic enhancer suppressor screens conducted with the gl-tau fly using published collections of LOF and gain-of-function (GOF) transposon insertions.
Historically thought of as only parasitic elements, recently it has become clear that the influence of transposons on genomic structure and function in vertebrates is complex [ 1- 4].
The above results suggest that BmAgo2 may function to maintain genome stability by suppressing the activities of transposons.
Presently, substantial research is going on to reveal the functions of piRNAs in the epigenetic and post-transcriptional regulation of transposons and genes.
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