As part of this role, the function of the highly extended D/E-rich domain in midasin could be to interact with positively-charged nuclear protein substrates in a manner analogous to the acidic regions of the nuclear transport GTPase Ran [ 51], the nuclear transporter Tpr [ 52], and the chromatin remodeling proteins of the SWI/SNF family [ 53].
The functions of these roles are described below.
Thus the inhibitory functions of this receptor play an important role in suppressing pathological inflammatory responses induced by this pathogen (Long et al., 2013).
An extended mutation analysis encompassing the hexapeptide of Engrailed might help to discriminate between the two functions of this domain and evaluate the actual role of Pbx.
The good prognostic effect conferred by the infiltrate's CXCL8 positivity most likely reflects the immune functions of this chemokine and the anti-tumour role of the inflammatory cells.
Fittingly, among the diverse functions of this transcription factor, its role in the kidney as a master regulator of vacuolar H+-ATPase proton pump subunits [ 8] might be an intriguing candidate function for climate adaptation through water-electrolyte homeostasis and prevention of dehydration.
The principal aim of this historical review- the first in a new series- is to present the basic concepts that led to the discovery of NOV and to show how our ideas evolved regarding the role and functions of this new class of proteins.
These results indicate that the developing sea urchin possesses a high-affinity choline transporter analogous to that found in the mammalian brain, and, as in mammals, the functioning of this transporter plays a key role in the developmental, trophic activity of acetylcholine.
More functions of torpor and their roles in a changing world.
The RI said it had taken the decision because its "requirement for the functions of the role of director as currently defined has ceased to exist".
Whether the observed difference in the molecular weight indicates a different function and role of this protein in M. tardigradum needs to be investigated in future experiments.
