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That done, the complicated functions of the kidney will clear the circulating blood of the retained waste products, and the body will have restored its own normal balance.
To understand the functions of the kidney, the transcriptome of each part of the nephron needs to be profiled using a highly sensitive and unbiased tool.
Cell therapy devices are currently being developed to replace the filtrative, metabolic, and endocrinologic functions of the kidney lost in both acute and chronic renal failure.
These RECs demonstrate differentiated absorptive, metabolic, and endocrine functions of the kidney when tested under in vitro and preclinical ex vivo animal studies.
Replacing the critical transport, metabolic, and endocrine functions of the kidney may provide more complete RRT, changing the natural history of these disease processes.
For patients with advanced disease, renal replacement therapies approximate the filtration functions of the kidney at considerable cost and inconvenience, while failing to restore the resorptive and endocrine functions.
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These processes are essential for the survival of ESRD patients, as the dialysis process substitutes, far from perfectly, for the excretory functions of the kidneys.
Serum creatinine and BUN are commonly used to assess glomeruli filtration rate as well as concentrating and diluting capacity of tubular functions of the kidneys.
One possible explanation is that metabolic complications may reflect both the endocrine and excretory functions of the kidneys and may not be sufficient to cause organ dysregulation.
"His work helped advance the field of kidney research by clarifying a fundamental function of the kidney that 50 years ago was not understood," said Dr. Gerhard H. Giebisch, a professor of cellular and molecular physiology at the Yale medical school.
However, the blood urea nitrogen values showed the normal function of the kidney in all rats.
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