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Decreased levels of vitamins A and E, and of Zn at calving might have negative implications for the functions of the immune defence.
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There is evidence that at least some entities within the group of PSV confer an altered function of the immune defence per se.
Although factors contributing to increased susceptibility to infection have not been fully elucidated, impaired neutrophil recruitment to the site of infection and changes in the concentrations of some micronutrients related with the function of the immune defence has been implicated.
Expression in the spleen is hardly surprising given the function of spleen in the immune defence.
Blood cells constitute one of the first lines of the immune defence system [ 16].
Furthermore, insufficient information of the immune defence mechanism against HIV-1 infection makes vaccine development an even more challenging task.
This suggests a possible function of NK cells in the immune defence process directed against E. coli in the mammary gland.
Interestingly, much of the virulence can be blamed on the seemingly misguided overresponse of the immune defences [ 11].
The observed elevation of inducible TNF-α production may contribute to the immune defence of the mother against infections.
Our results indicate that the distribution of the tight junctional protein ZO-1, the immune defence and vascular function are immature at low GA and are further compromised by endotoxin-induced chorioamnionitis.
The immune defence is a final line of protection and is therefore of great importance.
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