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Inhibitory functions of regulatory T cells are mediated by direct binding of CTLA-4 and by cytokine production [28], [50], [51].
In parallel to this clinical benefit, rituximab has been reported to modulate the numbers and functions of regulatory T cells and T cell effectors in several autoimmune diseases [5], [6].
When we sought to analyze the effects of combination therapy and full dose Etanercept therapy, it appeared evident that different functions of regulatory T cells were affected by the two treatments.
This highlights the disparate functions of regulatory region methylation with that of gene body methylation [ 54].
Lu and colleagues [ 35] recently demonstrated that miR-146a is critical for the suppressor functions of regulatory T (Treg) cells.
Coexpression analysis can facilitate prediction of functions of regulatory proteins that do not have enzymatic, transporter, or structural molecule activities.
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The function of regulatory T cells is poorly understood.
Impaired development and function of regulatory T cells.
Bacterial fermentation products regulate the number and function of regulatory T cells in the mouse colon.
As reported by national and international medias (cf. Foster, 2011), it is precisely because of these events that people started to seriously question the business ethics of the whole food industry and the proper function of regulatory authorities.
In addition, intestinal microbiota induces the production of GM-CSF by ILC3s, which promotes macrophages to produce retinoic acid and results in a tolerogenic state through enhancing function of regulatory T cells (Mortha et al., 2014).
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